铜催化碳杂偶联反应的新进展

Recent Progress in Copper Catalyzed Carbon-Hetero Cross-Coupling Reactions

某些过渡金属可催化亲电性不饱和碳与含活泼氢的氮、氧、硫、碳原子直接成键,这种交叉偶联反应是现代有机合成中重要的手段之一.与钯、镍等过渡金属相比,铜是一种廉价且毒性低的金属,用铜来催化这些交叉偶联反应不仅可以节省贵金属的消耗,降低成本,而且可以减少对环境的污染,促进绿色化学的发展.对铜催化碳杂键偶联反应的最新研究进展做了综述。

The transition metal-catalyzed cross-coupling reaction to form sp2 C--C or C-hetero atom bonds is one of the most important methods for modem organic synthesis. In comparison with Pd and Ni, copper is a cheap metal with low-toxicity. In this review the newest development of the Cu catalysts in C--N cross-coupling reactions is summarized.