碱性季铵盐“一锅法”催化合成四氢苯并[b]吡喃的水相反应研究

One-Pot Synthesis of Tetrahydrobenzo[b]pyran Catalyzed by Basic Quaternary Ammonium Salt in Aqueous Medium

报道了以2-二甲氨乙基苄基二甲基氯化铵为催化剂,在水相介质中"一锅法"催化芳醛、丙二腈和5,5-二甲基-1,3-环己二酮合成2-氨基-3-氰基-4-芳基-7,7-二甲基-5-氧代-4H-5,6,7,8-四氢苯并[b]吡喃的方法.该法具有产率高、反应时间短、操作简便、对环境友好、催化剂可重复使用等优点.

A synthesis of 2-amino-3-cyano-4-aryl-7,7-dimethyl-5-oxo-4H-5,6,7,8-tetrahydrobenzo[b]- pyrans from aromatic aldehyde, malononitrile and 5,5-dimethyl-1,3-dioxocyclohexane using （2-dimethylaminoethyl）（benzyl）dimethylammonium chloride （[PhCH2Me2N＋CH2CH2NMe2]Cl-） as catalyst （5 mol%） was described which provided several advantages such as excellent yield, short reaction time, simple ex- perimental and work-up procedure, reusability of catalyst and benignity to environment.