序贯疗法根除幽门螺杆菌的临床分析

The Study on Eradication of Helicobacter Pylori Using Sequential Therapy

目的:观察由潘托拉唑、阿莫西林、左氧氟沙星、克拉霉素组成的10日序贯疗法根除幽门螺杆菌(Helicobacter pylori,Hp)的疗效及安全性。方法:将经胃镜检查确诊为慢性胃炎或消化性溃疡且Hp阳性的患者115例随机分为两组,治疗组(58例)前5天口服潘托拉唑+阿莫西林,后5天口服潘托拉唑+克拉霉素+左氧氟沙星;对照组(57例)口服潘托拉唑+阿莫西林+克拉霉素,疗程7天,比较治疗后两组Hp根除率。结果:Hp根除率治疗组93.0%,对照组81.9%,两组间差异有统计学意义(P<0.05)。结论:以潘托拉唑、左氧氟沙星等组成的10日序贯疗法治疗Hp感染具有较高的根除率,安全性好。

Objective： To evaluate the eradication of ten days sequential therapy consisted of Pantoprazole, Clarithromycin, Amoxicillin and Levofloxacin on Helicobacter pylori（Hp） infection. Methods： Totally 115 Helicobacter pylori-infected patients with peptic ulcer or chronic gastritis diagnosed by gastroscopy were enrolled. The patients were randomized divided as trial group （58 patients） who received Pantoprazole, Levofloxaein for the first five days, and followed by Pantoprazole, Amoxicillin and Clarithromycin for the last five days; the control group （57 patients） were treated with Pantoprazole, Amoxicillin and Clarithromycin for seven days, then contrast the eradication rates. Results： The eradication rates of Hp in the trial group was 93.0%, and the numbers in the control group was 81.9%, which were significantly lower than those in the sequential therapy group （P〈0. 05）. Conclusions： The ten days sequential therapy consisted of Pantoprazole and Levofloxacin, Amoxicillin, Clarithromycin has a better H. pylori eradication effect and tolerability than standard triple therapy.