摘要
目的:观察中药和胃宝颗粒剂在体外培养条件下对幽门螺杆菌(Hp)生长的影响,以及和胃宝颗粒剂存在时Hp对几种常用抗生素敏感性的影响。方法:将Hp接种于含不同浓度和胃宝颗粒剂的布氏肉汤中培养,测定和胃宝对3种菌株的抑制直径的改变。E检测法检测和胃宝对甲硝唑等抗生素MIC的影响。结果:(1)和胃宝颗粒剂可抑制Hp的生长,这种抑制作用与甲硝唑大致相当,明显优于克拉霉素。(2)和胃宝颗粒剂存在时,分别使100%、75%及75%的Hp对甲硝唑及克拉霉素的MIC降低,提示和胃宝颗粒剂可使Hp对上述抗生素的敏感性增高。结论:和胃宝颗粒剂可抑制Hp的生长,提高Hp对甲硝唑、克拉霉素及羟氨苄青霉素的敏感性。
Objective:To research the effect to the growth of Helicobacter pylori by Heweibao Granule in vitro,and the effect to the sensitivity of normal antibiotics to Helicobacter pylori with Heweibao Granule. Methods:Inoculate Hp to medium with different concentrations of Heweibao Granule,then determine the inhibition extent change. And detect the effect of the antibiotics with Heweibao Granule.Results:(1) Heweibao Granule can inhibit the Hp as Metronidazole,better than Clarithromycin.(2)The MIC to Metronidazole and Clarithromycin of Hp can be depressed with Heweibao Granule.Conclusion:Heweibao Granule can inhibit the growth of Hp,increase the sensitivity of Hp to Metronidazole,Clarithromycin and amoxicillin.
出处
《辽宁中医药大学学报》
CAS
2010年第2期196-197,共2页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
和胃宝颗粒剂
消化性溃疡
中医药疗法
Heweibao Granule helicobacter pylori traditional Chinese medical therapy