有内置物的骨与关节感染诊断技术研究进展

Research in Progress of Diagnosis for Infection of Internal Fixation of Fractures or Arthroplasty

感染是骨科手术严重并发症之一,骨科手术量的增多、内植物在体内停留时间的延长及患者生存期的增长,感染细菌的耐药及细菌生物被膜的形成使得内植物术后感染的诊断与治疗非常棘手。单独任何一种常规检查对准确诊断感染是不够的,临床上常综合临床表现、实验室检查、组织病理和影像学结合起来进行诊断,近年来,感染的诊断技术有较大的进展,尤其是在核影像方面,99Tcm标记的抗菌素(环丙沙星)和FDG-PET技术虽然还处于研究阶段,但其对感染诊断特异性已大大提高。

Infection is one of serious complications in orthopedic surgery,which is difficult to cope with because of many reasons including more orthopedic surgeries and increasing-time of internal fixation in the bodies and drug resistance and the formation of biological membrane. Any kind of routine examination for accurate diagnosis of infection is not enough. Usually accurate diagnosis need to combine clinical manifestations,laboratory tests,histological and imaging examination. In recent years,there is a long progress in the diagnosis methods of infection,especially in the areas of nuclear image. Although still under study,Specific diagnosis of infection has greatly increased with 99Tcm-ciprofloxacin and FDG-PET technologies.