核苷类似物抗病毒治疗对慢性HBV感染者短期生存质量的影响

Early influence of life quality of patients with chronic HBV infection by antivirus treament with nucleoside analoges

目的:观察核苷类似物抗病毒治疗3个月对慢性HBV感染者生存质量的影响。方法:使用慢性肝病问卷(CLDQ)对慢性HBV感染者抗病毒治疗前及抗病毒治疗3个月进行生存质量评定,并分析抗病毒前后HBVDNA、ALT、AST、TBIL、ALB、PTA变化,了解抗病毒治疗对患者生存质量的影响与病毒载量、肝功能的变化之间的关系。结果:抗病毒治疗3个月后,患者的所有领域生存质量评分均高于治疗前(P<0.05),同时HBVDNA、转氨酶、总胆红素较治疗前下降(P<0.05)。结论:抗病毒治疗不但降低病毒载量、改善肝功能,同时可改善患者生存质量,对有抗病毒治疗指征的患者,应进行抗病毒治疗。

Objective To investigate the impact of life qualities of patients with chronic HBV infection after antiviral treatment of 3 months. Method The life qualities were assessed by CLDQ before and after treatment for 3 months,the changes of HBV - DNA,ALT,AST, TBIL, ALB and PTA were also tested. Results After anti - virus treatment for 3 months, the score of life quality was higher than pretreatment, and HBV - DNA, ALT, TBIL decreased than pretreatment. Conclusion Anti - virus treatment not only reduces HBV - DNA and improves liver functions, but also improves the life quality of patients with chronic HBV infection.