红花注射液预防化疗药物所致静脉炎的临床研究

Clinical observation of Honghua injection on preventing phlebitis caused by chemotherapeutics

目的:探讨红花注射液预防化疗所致浅表静脉炎的疗效。方法:将恶性肿瘤患者随机分成治疗组和对照组,治疗组用红花注射液10ml+5%GS250ml在含刺激血管壁的化疗药物使用的前、后静脉滴注。对照组除不用红花注射液外,其余止吐、对症支持治疗与治疗组相同。结果:应用红花注射液后静脉炎发生率明显下降,治疗组发生率为26.4%(29/110),对照组发生率62.4%(68/109),两组比较有显著性差异(P<0.05)。治疗组无红花注射液相关严重毒性反应发生。结论:红花注射液是预防化疗药物所致浅表静脉炎的有效药物之一,毒副反应小,疗效好。

Objective： To investigate .preventive effect of Honghua injection on chemotherapy-induced superficial phlebitis. Methods： The malignant tumor patients were randomly divided into treatment group and control group, treatment group received intravenous drip of Honghua injection（10 ml＋5 %GS 250 ml）before and after the use of chemotherapeutics which can stimulate vessel wall. Without using Honghua injection, the rest antiemetic and symptomatic treatment of control group were the same as treatment group. Results： The incidence of phlebitis decreased obviously after the application of Honghua injection,the rate of phlebitis in the treatment group is 26.4%（29/110） ,which was lower than that of control group（62.4% ,68/109） ,the difference was significant（P〈0.05）. There were not Honghua injection-related severe toxicity in the treatment group. Conclnsions： Honghua injection was one of the effective drugs to prevent chemotherapy-induced superficial phlebitis,with small toxicity and good curative effect.