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协同共刺激分子B7-H4与肿瘤关系的研究进展 被引量：1

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摘要 肿瘤是威胁人类健康的恶性疾病，在其发生发展过程中，T细胞活化和耐受的免疫调节起着至关重要的作用，其中B7-CD28家族成员介导的T细胞共刺激信号转导，不仅在启动、增强和维持T细胞应答中提供了关键的正性信号，而且还可提供重要的负性信号来限制、终止或削弱T细胞的免疫应答。
作者 左宏玲 杨艳华 徐春琳
机构地区 河北医科大学第二医院妇产科
出处 《河北医科大学学报》 CAS 2010年第1期116-118,共3页 Journal of Hebei Medical University
关键词 B7-H4 肿瘤 综述文献
分类号 Q786 [生物学—分子生物学]
  • 相关文献

参考文献18

  • 1CARRENO BM, COLINS M. B7 family of ligands and its receptors:new pathways for costimulation and inhibition of immune response [J]. Annu Rev Immunol, 2002,20 (1) : 29- 53.
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  • 3ZANG X,LOKE P,KIM J, et al. B7x: a widely expressed B7 family member that inhibits T cell activation[J]. Proc Natl Acad Sci, 2003,100(18) : 10388-10392.
  • 4PRASAD DV,RICHARDS S, MAI XM, et al. B7S1, a novel B7 family member that negatively regulates T cell activation [J]. Immunity, 2003,18 (6) : 863-873.
  • 5魏双燕,姜洁,南芳芳,成磊.卵巢浆液性癌B7-H4的表达及临床病理意义[J].现代妇产科进展,2008,17(7):493-496. 被引量：8
  • 6SIMON I, KATSAROS D, RIGAULT DL, et al. B7-H4 is over expressed in early-stage ovarian cancer and is independent of CA125 expression [ J]. Gynecol Oncol, 2007, 106(2) :334-341.
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  • 10MUGLER KC, SINGH M, TRINGLER B, et al. B7-H4 expression in a range of breast pathology: correlation with tumor T-cell infiltration [J]. Appl Immunohistochem Mol Mor Phol, 2007,15(4) : 363-370.

二级参考文献27

  • 1Aunoble B,Sanches R,Didier E,et al.Major oncogenes and tumor suppressor genes involved in epithelial ovarian cancer (review)[J].Int J Oncol,2000,16(3):567-576.
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共引文献20

同被引文献22

  • 1廖林虹,于晓红.B7-H4在卵巢浆液性癌组织中的表达及其临床意义[J].实用癌症杂志,2010,25(5):473-475. 被引量：2
  • 2Ratto C,Costa R,Vassallo C,et al.Twelve-year experience with left atrial resection in the treatment of non--small cell lung cancer [J].Ann Thorac Surg,2004,78(1 ):234-237.
  • 3Boyle P,Levin B.Wodd cancer report 2008 [M].Lyon Cedex : IARC Press, 2008:422-423.
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  • 5Tringler B,Liu W,Corral L,et al.B7-H4 overexpression in ovarian tumors[J].Gynecol Oncol, 2006,100( 1 ):44-52.
  • 6Sica G L,Choi I H,Zhu G,et al.B7-H4,a molecule of the B7 family,negatively regulates T cell immunity [J]. Immunity, 2003,18 (6) :849-861.
  • 7Prasad D V,Rieards S,Mal X M,et al.B7S1 ,a novel B7 family member that negatively regulates T cell activation [ J ] .Immunity, 2003,18 (6) :863-873.
  • 8Zang X ,Loke P, Kim J ,et al.B7x:a widely expressed B7 family member that inhibits T cell activation [J].Proc Natl Acad Sci USA,2003,100(18):10388-10392.
  • 9Zang X,Thompson R H,A1 Ahmadie H A,et al.B7-H3and B7x are highly expressed in human prostate cancer and associated with disease spread and poor outcome[J]. Proc Natl Acad Sci USA,2007,104(49):19458-19463.
  • 10TringIer B,Zhuo S,Pilkington G,et al.B7-H4 is highly expressed in ductal and lobular breast cancer [J].Clin Cancer Res, 2005,11 (5): 1842-1848.

引证文献1

二级引证文献1

河北医科大学学报
2010年 第1期

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