盐酸氨溴索与硫酸镁辅助治疗毛细支气管炎疗效观察

The Effect Observation of Ambroxol Hydrochloride and Magnesium Sulfate in Treating Bronchiolitis

目的:探讨盐酸氨溴索与硫酸镁辅助治疗毛细支气管炎的临床疗效。方法:43例毛细支气管炎患儿随机分为治疗组23例和对照组20例,两组均给予常规综合治疗,治疗组加用25%硫酸镁0.2～0.3mL/(kg·d),以5%葡萄糖注射液稀释成0.25%～0.5%浓度输液泵匀速静脉滴注3～5h,1次/d,连用3～5d,盐酸氨溴索15mg静脉推注,1次/d,疗程7～10d。结果:治疗组咳嗽、喘息的消退时间及住院天数分别为(4.68±1.07)d、(3.83±1.22)d、(5.81±1.34)d,对照组分别为(6.15±1.36)d、(5.46±1.48)d、(7.05±1.17)d,两组比较差异有统计学意义(t分别为3.9636、3.9587、3.2085,P均<0.01),两组病例治疗过程中均未见明显不良反应。结论:盐酸氨溴索与硫酸镁辅助治疗毛细支气管炎安全、有效。

Objective：To investigate the effect of ambroxol hydrochloride and magnesium sulfate as an adjuvant treatment of bronchiolitis. Methods： Forty three children with bronchiolitis were randomly divided intoa treatment group of 23 cases and a control group of 20 cases. Both groups accepted same routine treatment, but the treatment group was treated additionally with 25% magnesium sulfate plus 0.2 -0.3 mL/（ kg· d）, 5% glucose injection diluted into 0.25% -0.5% concentration in a way of infusion pump infusion uniform 3 - 5 h, once a day, for 3-5 days, and 15 mg intravenous injection of ambroxol hydrochloride, once a day for 7 - 10 days. Results： In the treatment group, the regression times of coughing, gasping and hospitalization were （4.68±1.07, 3.83 ± 1.22, 5.81 ± 1.34） d, however those of the control group were （6.15±1.36, 5.46 ± 1.48, 7.05 ± 1.17） d, there were statistically significant difference （t = 3. 9636, 3. 9587, 3. 2085, all P 〈 0. 01 ）. Two groups of patients showed no obvious adverse reactions during treatment. Conclusions： Ambroxol hydrochloride and magnesium sulfate adjuvant treatment of bronchiolitis is safe and effective.