孟鲁司特钠治疗毛细支气管炎临床疗效观察

The Clinical Observation of Montelukast in Treating Bronchiolitis in Children

目的：探讨孟鲁司特钠治疗毛细支气管炎的临床疗效。方法：78例毛细支气管炎患儿随机分成观察组40例和对照组38例，两组均采用相同综合治疗，观察组加服孟鲁司特钠，6个月以下2．5mg／d，6个月以上4mg／d，每晚服用1次，疗程至症状和体征消失，观察气促、咳嗽、肺部体征改善时间。结果：观察组总有效率（95．0％）明显高于对照组（81．5％），两组比较差异有统计学意义（x^2=7．22，P〈0．05）。结论：孟鲁司特钠治疗毛细支气管炎可缩短病程、减轻喘憋程度，无明显不良反应，可作为毛细支气管炎的辅助用药。

Objective：To study the clinical efficacy of montelukast in the treatment of bronchiolitis. Methods： Seventy eight infants with bronchiolitis were randomly divided into two groups. One was observation group （ n = 40 ）, the other was control group （ n = 38 ）. Each group was treated with combined therapy. Montelukast was added in the observation group. The improvement time of symptoms and physical signs in the observation group was observed. Results： The total effective rate of observation group （95.0%） was higher than that of control group （81.5%） , the difference was significant （X^2 =7.22, P 〈0.05）. Conclusions： It could shorten the duration of illness, abate the asthmatic suffocating symptoms and speed up the cure with montelukast in the treatment of bronehiolitis. Montelukast can be used in the treatment of bronehiolitis.