口服黄连素治疗小儿室性早搏36例疗效观察

An Observation of Oral Berberine on 36 Children with Ventricular Premature Beats

目的:观察黄连素治疗小儿室性早搏的疗效和不良反应。方法:我院从2002年5月～2009年5月共收治小儿室性早搏患儿72例,随机分为治疗组和对照组各36例,治疗组口服黄连素15～20mg/(kg·d),最大剂量不超过0.4g/d,分3次口服,对照组口服胺碘酮2.5～5mg/(kg.次),3次/d,3d后减为2次/d,7d后改为维持量1次/d口服,比较两组有效率和不良反应发生率。结果:治疗组总有效率83.33%,对照组总有效率86.11%,两组比较差异无统计学意义(χ2=0.11,P>0.05),治疗组不良反应发生率5.5%,对照组不良反应发生率22.2%,两组比较差异有统计学意义(χ2=4.18,P<0.05)。结论:口服黄连素对小儿室性早搏疗效和胺碘酮稍差或相当,不良反应明显小于胺碘酮,值得临床进一步研究和探讨。

Objective：To observe the curative effects and side effects of berberine used to treat children with ventricnlar premature contract. Methods： From May 2002 to May 2009, our hospital had treated totally 72 cases of children with premature ventrieular contraction. They were randomly divided into two groups, the treatment group and the control group. And each of them had 36 cases. The treatment group took berberine 15 - 20 mg/（ kg · d） orally while the control group took 2.5 - 5 mg/（ kg · d） of amiodaron three times a day, three days later, it was reduced to two times a day and seven days later, once a day only for maintenance dose. Results： Through comparing their effective rates and the rates of their adverse effects of two groups, the total effective rate of the treatment group was 83.33% and that of the control group was 86.11%. The difference between the two groups had no statistical significance （X^2 = 0. 11, P〉0.05）. The adverse drug reaction of the treatment group was 5.5% and that of the control group was 22.2%. The difference had statistical significance （X^2 =4.18, P 〈 0.05 ）. Conclusions： The oral administration of berberine to children with ventricular premature contraction are less efficient than amiodaron, or corresponded to it, and obviously the adverse drug reaction of the treatment group is less than that of amiodaron, which is worth further clinical study and discussion.