疏肝导浊方对脂肪肝家兔的AST、ALT、ALP、NO、SOD和MDA的影响

The effect of Shugandaozhuo medicine on AST,ALT,ALP,NO,SOD and MDA in rabbit with fatty liver

[目的]观察疏肝导浊方对脂肪肝家兔肝功能及抗氧化作用的影响。[方法]采用高脂饲料喂饲家兔6周,诱导形成脂肪肝模型,实验分组为疏肝导浊方高、中、低(8、4、2g/kg)剂量组、东宝肝泰对照组、模型组和空白对照组,检测各组肝功能、超氧化物歧化酶(SOD)、丙二醛(MDA)、一氧化氮(NO)水平。[结果]模型组肝功能、SOD明显下降(P<0.05),MDA明显增加(P<0.01);疏肝导浊方中、低剂量组SOD明显升高(P<0.05)。[结论]疏肝导浊方可有效提高脂肪肝家兔的抗氧化作用。

[Objective] To observe the effects of Shuogandaozhuo Medicine （dispersing stagnation of liver-Q and reducing the turbid pathogen, SM） on liver function and its anti-oxygenation in rabbits with fatty liver. [Methods] The fatty liver in rabbits was induced by feeding them with high caloric diet for six weeks. Sixty rabbits were randomly divided into six groups including the high-dose, middledose and low-dose SM groups, the Dongbaogantai group, the model group and the normal control group. The liver index （liver weight/body weight）, the amount of AST, ALT, ALP, NO, SOD and MDA in the serum were investigated after medication. [Results] The liver function and the amount of SOD decreased significantly （P〈0.05） in the model group with significant increasing of the MDA （P〈0.01）; Significant increase of SOD was found in the middle and low-dose of the SM group （P〈0.05）. [Conclusion] SM is effective for increasing anti-oxidation in rabbits with fatty liver.