甲基强的松龙治疗慢性阻塞性肺疾病急性加重期的临床观察

Clinical observation of Methylprednisolone in the treatment of chronic obstructive pulmonary disease with acute exacerbation

目的:观察静脉用甲基强的松龙对慢性阻塞性肺疾病急性加重期治疗的临床疗效及意义。方法:将轻中度COPD患者30例及重度COPD患者32例均随机分为两组,分别以抗感染、祛痰、雾化、扩张支气管、控制性氧疗等作为基础治疗,治疗组加用甲基强的松龙,组间分别进行疗效观察。结果:轻中度COPD静脉甲基强的松龙治疗组疗效与对照组比较,差异无统计学意义(P>0.05)。重度COPD静脉甲基强的松龙治疗组疗效与对照组比较,差异有统计学意义(P<0.05)。结论:在抗感染、祛痰、扩张支气管等治疗基础上,短期、适量应用全身糖皮质激素对急性加重期的重度COPD患者肺功能有明显的改善作用,临床疗效明显,而对急性加重期的轻中度COPD患者作用不明显。

Objective：To observe the clinical efficacy and significance of intravenous Methylprednisolone in the treatment of chronic obstructive pulmonary disease with acute exacerbation.Methods：30 cases of mild to moderate COPD patients and 32 cases of severe COPD patients were randomly divided into two groups each,they were respectively given anti-inflammatory,expectorant,atomization,expansion bronchus,controlled oxygen therapy,etc.,the treatment group with intravenous Methylprednisolone.Comparison of curative effect between the two groups were observed separately.Results：The use of Methylprednisolone treatment of mild to moderate COPD compared with control group,no significant difference in efficacy （P〉0.05）.However,significant effect of severe COPD group （P〈0.05）.Conclusion：Using antibiotics,a short-term,regular application of systemic glucocorticoids in acute exacerbation of severe COPD patients has significant improvement in lung function effects and clinical efficacy,while acute exacerbation in patients with mild to moderate COPD is not obvious.