中西医结合根除幽门螺杆菌90例临床观察

Clinical observation on 90 cases of integration of Traditional Chinese and Western Medicine on eradication of Hp

目的:观察中西医结合临床根除幽门螺杆菌感染的效果。方法:经胃镜和组织学检查,选择280例Hp阳性消化性溃疡患者,随机分为三组。中西医结合组90例,给予"三黄灭幽汤",每天1剂,同时口服奥美拉唑胶囊,1次20mg,每天2次;西药三联组90例,给予克拉霉素片0.25g,甲硝唑片0.4g,奥美拉唑胶囊20mg,每天2次,均口服;中药组100例,给予"三黄灭幽汤",每天1剂,疗程均为4周,疗程结束后4周复查14C-UBT。结果:中西结合组、西药三联组及中药组Hp根除率分别为92.22%,74.44%及71.00%;溃疡愈合率分别为91.11%,73.33%及72.00%。中西医结合组与西药三联组、中药组比较,均有非常显著性差异(P<0.01)。不良反应轻微,未见严重的肝、肾不良反应。结论:中西医结合根除幽门螺杆菌感染疗效确切,依从性好,不良反应少,可作为二线治疗方案。

Objective：To observe the clinical effect of integration of Traditional Chinese and Western Medicine （TCWM） on eradication of Hp infection.Methods：By gastroscopy and histology test,a total of 280 patients of Hp positive peptic ul cer were randomized into 3 groups.The TCWM group （90 cases） was treated by one dose of ＂San Huang Mie You Tang＂ per day and Omeprazole 20 mg twice a day for 4 weeks.The TWM group （90 cases） was treated by Clarithromycine 0.25 g,Metronidazole 0.4 g and Omerazole 20 mg twice a day for 4 weeks.The TCM group （100 cases） was treated by one dose of ＂San Huang Mie You Tang＂ per day for 4 weeks.14C-UBT was detected 4 weeks after the treatment was over.Results：In the TCWM,TWM and TCM group,the Hp eradication rates were 92.22%,74.44% and 71.00% respectively,the healing rates of peptic ulcer were 91.11%,73.33% and 72.00% respectively.The TCWM group vs the TWM group or vs the TCM group,there was a significant difference （P〈0.01）.The adverse reactions were mild,no severe liver or kidney adverse reactions were found.Conclusion：Integration of TCWM has good effect on eradication of Hp infection,it shows good compliance with few side effects so that it can be the choice of second-line treatment.