摘要
目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者与血清尿酸水平及血脂代谢的相关性,进一步认识OSAHS在心血管疾病发病过程中的作用。方法:68例患者均采用美国邦德公司的16导睡眠监测仪监测系统确诊,于入院后24h内的第一个清晨静卧,空腹抽取肘静脉血液标本测定血清尿酸水平,健康对照组(经体检证实健康者62例)为同一时间抽血检测相同项目;依据呼吸暂停低通气指数(AHI)结果,将患者分为轻(18例)、中(32例)、重度(18例),与健康对照组(62例)血脂结果比较。结果:OSAHS患者的血清尿酸水平显著高于正常对照组(P<0.05),在不同程度OSAHS中差异有统计学意义(P<0.05),血清尿酸水平、最低血氧饱和度、体重指数和OSAHS病情严重程度呈正相关;OSAHS组总胆固醇(TC)、三酰甘油(TG)、载脂蛋白B、脂蛋白(a)高于对照组,两者比较,差异有统计学意义(P<0.01)。结论:OSAHS患者血清尿酸水平升高,可作为判断OSAHS患者严重程度的体液指标;OSAHS可引起脂代谢紊乱,积极治疗是防治心血管疾病的重要环节。
Objective： To explore the correlation of obstructive sleep apnea-hypopnea syndrome （OSAHS） patients and serum uric acid levels and lipid metabolism; and to find a better understanding of the pathogenesis of OSAHS in cardiovascular disease. Methods： 68 patients were used by the U.S. Bond＇s 16-channel monitoring system for diagnosis of sleep monitor, were admitted to hospital within 24 h after the first morning lying still, fasting venous blood samples taken elbow serum uric acid levels of healthy control group （confirmed by physical examination healthy 62 cases） for the same time, blood tests to check the same items; based on apnea-hypopnea index（AH1） results, patients were divided into light （18 cases）, middle （32 cases）, severe （18 cases）, and healthy control group（62 cases） comparison of blood lipids. Results： OSAHS patients with serum uric acid level were significantly higher than the normal control group （P〈0.05）, OSAHS in varying degrees, the difference was statistically significant（P〈0.05）, serum uric acid level, the lowest oxygen saturation, body mass index and OSAHS severity of disease was positively correlated; OSAI-IS group total cholesterol （TC）, triglyceride （TG）, apolipoprotein B, lipid protein （a） control group, the difference was significant （P〈0.01）. Conclusion： OSAHS patients with elevated levels of serum uric acid can be used as to determine the severity of OSAHS patients with body fluids, indicators; OSAHS can cause lipid metabolism disorders, active treatment is an important part of prevention and treatment of cardiovascular disease.
出处
《中国当代医药》
2010年第4期11-13,共3页
China Modern Medicine
