186例异常胎儿染色体核型分析

Analysis of 186 cases unusual fetus chromosome

目的:通过对产前彩超检查出的异常胎儿进行脐血染色体分析,了解胎儿异常与染色体异常的关系。方法:2007年10月～2009年9月来本院进行产前检查的孕妇,彩超检查出186例胎儿结构异常,有176例选择引产,10例将异常胎儿娩出,无论引产还是分娩都进行脐血染色体检查。结果:染色体异常11例,其中数目异常5例,占45.5%,染色体缺失1例,占9.1%,染色体倒位3例,占27.3%,平衡异位1例,占9.1%,染色体变异来自父亲1例,占9.1%。结论:因许多严重的畸形与染色体异常有关,因此产前彩超检查出有明显结构异常时,应首先考虑行染色体检查以明确诊断,防止再次出生缺陷,提高人口素质,减轻家庭和社会的负担。

Objective ： The prenatal color super inspection of the abnormal fetus in cord blood genome analysis and understanding through the fetus abnormalities and chromosomal abnormalities. Methods：From October 2007 to September 2009 to our hospital for prenatal care for pregnant women, Super checks for 186 cases fetus structure unusual, 176 legislation select induced abortion, 10 cases of abnormal fetus. Agreeable, regardless of whether induced abortion or delivery for cord blood chromosome tests. Results：Chromosomal aneuploidy 11, the number of unusual 5, accounted for 45.5% chromosome missing 1 （9.1%）, chromosome down three laws, accounting for 27.3%. The balance different 1 （9.1%）, From his father, chromosome mutation 1 （9.1%）. Conclusion：Due to many serious deformities and chromosomal abnormalities and therefore prenatal color super inspection, a clear structure exception, should first consider the chromosome tests in a clear diagnosis and prevention of further birth defects and improve population quality, reduce family and social burden.