提高红色基ITR贝司收率的合成工艺研究

Improvement in Yield on the Synthesis of Fast Red-ITR Base

本文以邻氨基苯甲醚为原料，经乙酰化、氯磺化、胺解及水解反应，合成了３－氨基－Ｎ，Ｎ－二乙基－４－甲氧基苯磺酰胺（即红色基ＩＴＲ贝司）。对影响产品收率的工艺条件进行了研究。实验表明，在邻氨基苯甲醚乙酰化中，采用母液套用盐析工艺、氯磺化、胺解及水解三步反应不经干燥连续进行时，所得产品总收率为８３３％（以邻氨基苯甲醚计）。

Abstract In this thesis,the synthesis of 3-amino-N,N-diethyl-4-methoxybenzenesulfonamide (Fast Red ITR Base) was studied.It was prepared from o-amino anisole by acetylation、chloro-sulfonation、amination and hydrolysis.A total yield of 83 3% was given.