奥氮平、氯氮平、利培酮、喹硫平对首发精神分裂症患者P50感觉门控的影响

The effects of olanzapine, clozapine, risperidone and quetiapine treatment on P50 sensory gating in first-ep- isode schizophrenics

目的比较几种非典型抗精神病药对首发精神分裂症患者P50感觉门控的影响。方法运用条件一测试刺激模式和刺激序列模式检测36例正常对照和53例首发精神分裂症患者治疗前后PS0听觉诱发电位，比较治疗前后P50感觉门控的差异。结果治疗前，各药物组T—P50波幅、P50抑制，5．1Hz，9．9Hz高频刺激PS0波幅、PS0抑制与正常对照组比较[（条件-测试刺激模式T—P50波幅（1．01±0．88）μV，P50抑制（0．61±0．27）；刺激序列模式P50波幅（0．68±0．64）μV、（0．58±0．47）μV，P50抑制（0．54±0．22、（0．59±0．19）差异有显著性俨〈0．05）]。各药物组间比较差异无显著性（P〉0．05）；治疗后，各药物组自身前后比较上述PS0波幅、P50抑制差异均有显著性（P〈0．05）。与正常对照组比较，T—PS0波幅、P50抑制奥氮平组、氯氮平组差异无统计学意义（P〉0．05），利培酮组、喹硫平组差异有统计学意义（P〈0.05），5．1Hz，9．9Hz高频刺激P50波幅、PS0抑制各组均无统计学差异（P〉0．05）。结论各种非典型抗精神病药对P50感觉门控功能具有不同的影响；条件一测试刺激模式和刺激序列模式P50感觉门控可能具有不同的中枢神经机制。

Objective To compare the effects of atypical antipsychotics treatment on P50 sensory gating in first-episode schizophrenics. Methods The P50 auditory evoked potential was recorded by using eonditioningtesting stimulus paradigm and stimulus train paradigm in 36 normal controls and 53 first-episode schizophrenics before and after treatment, and compare the difference of 1950 sensory gating after treatment. Results Before treatment, compared with control group, the atypical groups both had statistic difference of T-PSO amplitude（ （ 1.01 ± 0. 88） μV, （0.68 ±0.64 ）μV, （0.58 ± 0.47 ） μV）, P50 suppression （ （ 0.61± 0.27 ）, （ 0.54 ± 0.22, （ 0.59 ±0. 19）） in conditioning-testing stimulus paradigm and P50 amplitude,P 50 suppression evoked by high frequency stimuli in stimulus train paradigm（P 〈 0.05）, but no difference among the atypical groups（P〉 0.05）. After treatment, compared with control group, there was no statistic difference in olanzapine and clozapine groups of T-PSO amplitude and P50 suppression in condltioning-testing stimulus paradigm, but the difference in risperidone and quetiapiue groups still obviously （P 〈 0.05 ）. In stimulus train paradigm, there was no statistic difference of P50 amplitude,P50 suppression evoked by high frequency stimuli in every groups （P 〉 0.05 ）. Compared within atypical groups, the difference of P50 amplitude and PSO suppression were both obviously（P〈 0.05 ）. Conclusion Each atypical antipsychotic has different effect on P50 sensory gating;and the conditioning-testing stimulus paradigm and stimulus train paradigm P50 sensory gating may reflect different central neuron mechanism.