多囊卵巢综合征糖耐量与谷氨酸脱羧酶抗体测定分析

Analysis of GAD Antibody in 73 Patients with PCOS

目的探讨多囊卵巢综合征(PCOS)患者糖耐量与谷氨酸脱羧酶抗体(GADA)的关系。方法选择PCOS患者73例,其中糖耐量正常(A组)35例;糖耐量异常(B组)38例。比较两组患者年龄、内分泌及糖耐量、胰岛素释放实验和GADA指标是否存在差异。依据GADA检测结果再将73例分组,27例GADA阳性(C组),46例阴性(D组),比较两组患者年龄、内分泌及糖耐量和胰岛素释放实验是否存在差异。结果GADA阳性27例,阳性率为36.9%。B组患者的体质量指数明显高于A组;B组患者空腹血糖(FPG)和餐后2h血糖以及餐后2h的胰岛素水平明显高于A组,有统计学差异。B组空腹胰岛素水平、GADA水平均高于A组,但无统计学意义。A,B组患者年龄、不孕时间、基础内分泌检测无统计学意义。C,D组患者年龄、不孕时间、体质量指数及糖耐量和胰岛素释放试验无统计学意义。结论尽管GADA是一种检测成人隐匿性自身免疫性糖尿病(LADA)的有效指标,但PCOS患者糖代谢与GADA的关系仍需进一步研究。

Objective：to investigate the relationship between glucose metabolism and GADA in PCOS patients.Methods：Seventy-three PCOS patients who attended to our center from 2009-5 to 2009-10 are divided into 2 groups：group A has 35 patients whose glucose tolerance test are normal while group B has 38 patients whose glucose tolerance test are abnormal.The same 73 patients are divided again according to the GADA test：group C has 27 patients who are GADA positive while group D has 46 patients who are GADA negative.The differences of age,BMI,endocrine test,glucose and insulin releasing test and GADA results between group A,B and group C,D were compared.Results：Twenty-seven patients are the GADA positive and the positive rate is 36.9%.The BMI,FPG,2h glucose and insulin releasing test in group B are higher than those in group A.Fasting insulin and GADA test in group B are higher than those in group A which showed no statistical differences.There are no differences of age,infertile time and endocrine test between group A,B and group C,D.Conclusions：Further research is needed to illustrate the relationship between PCOS and LADA even though the GADA is an effective index to diagnose the LADA.