微小RNA和生殖

Micro RNA and Reproduction

微小RNA(microRNA,miRNA)是一种长度约19～25个核苷酸的非编码RNA,通过碱基互补配对与mRNA的3’非翻译区结合降解靶基因或抑制其翻译,进行转录后负调控。迄今,上千种miRNA得到成功鉴定。miRNA不但在细胞的增殖、分化、凋亡、组织更新和干细胞分化过程中发挥作用,且参与生殖细胞发育、成熟和胚胎早期发育、激素分泌等生殖调节。

MicroRNA,a class of noncoding RNA of approximately 19-25 nucleotides,which can regulate gene expression by binding to the region of 3＇UTR of the target mRNAs to degrade or suppress target genes,is a post-transcriptional regulation.At present,thousands of microRNAs have been identified successfully.It is demonstrated that microRNA play an important role in cellular proliferation and apoptosis,self-renewal,stem cell differentiation,as well as in the development of germ cell and embryo,the regulation of hormone secretion.