Livin蛋白在肾癌中的表达及意义

Research on expression of livin in human renal cell carcinoma

目的观察凋亡蛋白抑制因子Livin在肾癌组织中的表达及其临床病理意义。方法采用免疫组化法检测54例肾癌中Livin蛋白的表达。结果Livin蛋白在肾组织中的阳性率明显低于肾癌组织。结论Livin蛋白表达增高与肾癌的临床分期、复发密切相关。检测Livin有助于提高肾癌侵袭转移能力的评估,并可作为判定肾癌生物学行为的客观指标。

Objective To investigate the expression of livin in renal cell carcinoma. Methods 54 cases of renal cell carcinoma were evaluated for livin protein expression by immunohistoehemical method. Results The positive expression level of livin in normal renal tissues was lower than that in renal cell carcinoma. Conclusion Increased expression of livin is markedly correlated with clinical classification of renal cell carcinoma and lymph node metastasis. Detection of livin may be helpful to evaluate prognosis and infiltrative capability of renal cell carcinoma.