治疗磺脲类降糖药继发性失效的疗效对比观察

Comparative study on treatment efficacy of secondary failure to sulfonylurea drugs

目的观察磺脲类降糖药继发性失效的糖尿病患者采用不同的降糖治疗对患者FGP及HbA1C的控制效果。方法64例患者随机分为两组,治疗组采用诺和锐30加罗格列酮及二甲双胍治疗;对照组采用诺和灵N加罗格列酮和二甲双胍治疗,疗程均为3个月。结果两组FGP及HbA1C均显著下降。治疗组FGP及HbA1C治疗前后具有显著差异性(P<0.01);对照组具有显著差异性(P<0.05)。结论诺和锐30加罗格列酮、二甲双胍能更好控制FGP、HbA1C,并能升高C肽,不引起肝功能损害。

Aim To observe the effect of different glucose-lowering therapy on patients with FGP and HbA1C. Methods 64 patients were randomly divided into two groups. The treatment group was cured with aspart 30 Jialuo Ge pioglitazone and metformin. The contrast group was cured with Novolin N Jialuo Ge rosiglitazone and metformin treat- ment. Both Treatments lasted for three months. Results FGP and HbA1C of the two groups were significantly decreased. FGP and HbA1C of treatment group before and after treatment showed significant difference （P〈0. 01）. Conclusion Novolin 30R Jialuo Ge pioglitazone and metformin can better control FGP, HbA1C and increase C-peptide without causing liver damage.