硝苯地平治疗高原性肺水肿63例临床观察

Treatment of high altitude pulmonary edema with nifedipine

目的观察硝苯地平治疗急性高原性肺水肿的临床疗效。方法将100例高原性肺水肿患者随机分为治疗组和对照组,均给予半坐卧位或坐位休息,50%酒精湿化鼻导管给氧、镇静、氨茶碱、地塞米松、强心甙、抗炎、对症等治疗,治疗组加用硝苯地平10mg,舌下含化,每日2次。比较两组患者在紫绀消失,心累气促、肺部啰音消失时间及住院时间的差异。结果治疗组在紫绀消失,心累气促、肺部啰音消失时间及住院时间上与对照组比较,有显著性差异(P<0.05)。结论硝苯地平对高原性肺水肿有较好的临床疗效,可在临床推广应用。

Objective To observe the clinical effieaey of nifedipine on acute high altitude pulmonary edema. Methotis 100 high altitude pulmonary edema were randomly divided into treatment and control groups. The patients were treated with nasal catheter oxygen inhalation, conscious-sedation, aminophylline, dexamethasone and cardiotonic glycoside. In addition, the treatment group were treated with nifedipine. The difference on cyanosis extinction, short breath, extinction time of lung rales and hospital day were observed. Result There was significant difference（P^0. 05） between two groups on cyanosis extinction, short breath, extinction time of lung tales and hospital day. Conclusion Nifedipine has good clinical efficacy on high altitude pulmonary edema.