子痫前期患者血清及胎盘抑制素A水平变化

Changes of inhibin A levels in serum and placenta in patients with preeclampsia

目的:探讨子痫前期患者血清及胎盘抑制素A的水平变化及其与病情的关系。方法:采用酶联免疫分析法检测40例子痫前期患者(子痫前期组,包括20例轻度、20例重度)、40例正常妊娠妇女(正常妊娠组)的血清抑制素A的水平;采用免疫组织化学方法检测胎盘抑制素A的水平。结果:子痫前期组患者血清、胎盘抑制素A水平[(4.82±0.13)、(497.35±6.75)μg/L]高于正常妊娠组[(1.65±0.08)、(262.34±13.35)μg/L],P<0.01;重度子痫前期组患者血清、胎盘抑制素A水平较轻度子痫前期组升高(P<0.01);子痫前期组患者血清、胎盘抑制素A水平与24h尿蛋白含量间呈显著正相关;重度子痫前期伴胎儿生长受限(FGR)组胎盘抑制素A水平较不伴FGR者差异无统计学意义(P>0.05)。结论:子痫前期患者血清、胎盘抑制素A水平较正常妊娠妇女显著升高,且与子痫前期病情进展关系密切。

Objective： To explore the changes of inhibin A levels in serum and placenta in patients with preeclampsia and the rela- tionship with degrees of preeclampsia. Methods： The serum levels of inhibin A from 40 patients with preeclampsia （ preeclampsia group, 20 patients with mild preeclampsia and 20 patients with severe preeclampsia） and 40 normal pregnant women （control group） were detected by enzyme - linked immunosorbent assay （ELISA） , while the levels of inhibin A in placenta from preeclampsia group and control group were detected by histochemistry method. Results： The levels of inhibin A in serum and placenta in preeclampsia group [ （4. 82± 0. 13 ） μg,/L, （497.35±6. 75） μg/L] were significantly higher than those in control group [ （ 1.65±0. 08） μg/L, （262. 34 ±13.35） μg/L] （ P 〈 0. 01 ） . The levels of inhibin A in serum and placenta in severe preeclampsia group were significantly higher than those in mild preeclampsia group （ P 〈 0. 01 ） . There was a positive correlation between levels of inhibin A in serum and placenta in preeclampsia group and 24 - hour proteinuria level. In preeelampsia group, there was no significant difference in inhibin A level in placenta between those with fetal growth retardation and those without fetal growth retardation （P 〉 0. 05 ） . Conclusion ： The levels of inhibin A in serum and placenta in patients with preeclampsia are significantly higher than those in normal pregnant women, which are related to degrees of the disease.