1,3-氧氮杂环戊烷类化合物在Chiralcel OD上的对映异构体拆分

Enantioseparation of 1,3-oxazolidine derivatives on Chiralcel OD

2位取代的5-氯甲基-1,3-氧氮杂环戊烷衍生物具有两个手性中心,有多种生理和生物活性.利用Chiralcel OD手性柱,首次对通过非手性选择性合成的2,3-二苯基-5-氯甲基-1,3-氧氮杂环戊烷和2-(4′-硝基苯)-3-苯基-5-氯甲基-1,3-氧氮杂环戊烷进行手性拆分研究.考察了流动相中极性添加剂以及柱温对拆分的影响.初步探讨了其手性识别的作用机理.发现在正相体系下溶质的4个对映异构体都获得了很好的拆分.

The enantioseparations of 2,3-diaryl-5-chloro- methyl-1, 3 oxazolidines and 2-（4^-nitro）- aryl, 3-aryl-5- chloro-methyl-1,3-oxazolidines were performed firstly on polysaccharide derivative-based CSP Chiralcel OD. This study showed the advantages of Chiralcel OD for the enantiomeric separation of these oxazolidine derivatives. The influence of variation of polar alcohol modifier concentration and the type in mobile phase hexane on the chiral sepa- ration was investigated, and variation of column temperature as well. Then the chiral recognition mechanism was discussed.