摘要
目的探讨桃红四物汤促进内皮细胞增殖及其初步机制。方法以10%浓度的高、中、低剂量组含药血清和空白对照组血清培养HU-VECs,观察其对HUVECs增殖、eNOS活性和NO分泌的影响。结果3种剂量的含药血清能均促进HUVECs增殖、eNOS活化和NO分泌。结论桃红四物汤通过上调eNOS-NO介导的信号途径,诱导内皮细胞增殖。
OBJECTIVE To investigate the effect of Taohong Siwu Decoction induce endothelial cells proliferation, its premiliary mechanisms. METHODS HUVECs were incuhated with blank serum, Taohong Siwu Decoction containing serum at final concentration of 10 %. The effect of Taohong Siwu Decoction on proliferation, eNOS activity and NO secretion were observed. RESULTS Taohong Siwu Decoction containing serum promoted the proliferation, eNOS activity and NO secretion of HUVECs. CONCLUSION Taohong Siwu Decoction can induce HUVECs proliferation via upregulating eNOS-NO-mediated pathwaway.
出处
《海峡药学》
2010年第1期39-41,共3页
Strait Pharmaceutical Journal
关键词
桃红四物汤
细胞增殖
血清药理学
一氧化氮
Taohong Siwu Decoction
Cell proliferation
Serum pharmacology
Nitric oxide
