沐舒坦佐治新生儿肺炎疗效观察

The efficacy of ambroxol in the treatment of neonatal pneumonia by different administration

目的探讨沫舒坦不同给药途径治疗新生儿肺炎的疗效。方法将2007年1月-2008年12月我科确诊为新生儿肺炎180例，随机分成4组，其中对照组采用吸氧，青霉素或头抱三嗪抗感染，补液等常规处理；（静脉静滴）治疗组1在对照组基础上加用沐舒坦静滴；（雾化）治疗组2在对照组基础上加用沐舒坦用氧气作驱动力雾化吸入；（静脉静滴＋雾化）治疗组3在对照组基础上加用沐舒坦静滴及沐舒坦用氧气作驱动力雾化吸入。结果治疗组在临床症状、体征及住院日均短于对照组（P〈0．01及P〈0．05），治疗组疗效优干对照组，差异有统计学意义。结论沐舒坦无论是静脉滴注还是雾化吸入治疗新生儿肺炎具有疗效显著．安全．基层医院可以应用。

OBJECTIVE To investigate the different routes of administration of ambroxol efficacy of the treatment of neonatal pneumonia. METHODS From January 2007-December 2008 180 cases diagnosed as neonatal pneumonia were randomly divided into four groups, including the control group were treated with oxygen, penicillin or ceftriaxone anti-infection, fluid replacement and otherconventional treatment; （intravenous static drops） in the treatment group 1 in the control group was added ambroxol on the basis of infusion; （spray） in the treatment group 2 in the control group was added ambroxol on the basis of oxygen as the driving force aerosol inhalation; （intravenous infusion ＋ spray） treatment group, three in the control group was added based on the intravenous ambroxol and ambroxol as driving force for oxygen inhalation. RESULTS The clinical symptoms, signs and in-patient day of the treatment group shorter that of control group （P 〈 0.01 and P 〈 0.05）, treatment group was more effective than the control group, the difference was statistically significant. CONCLUSION Ambroxol either intravenous infusion or inhalation treatment of neonatal pneumonia has a significant effect, safety, basic hospital can be applied.