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缬沙坦对高血压病患者胰岛素抵抗的影响 被引量:3

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摘要 目的探讨血管紧张素Ⅱ受体阻滞剂(ARB)缬沙坦降压的同时对胰岛素抵抗(IR)的影响。方法60例原发性高血压患者口服缬沙坦初始量80~160mg。每天早晨口服.少数疗效不显著加服氨氯地平5mg·d^-1。治疗12周后。采静脉血测定空腹胰岛素及空腹血糖.计算胰岛素敏感性数。结果高血压组治疗后血压较治疗前明显改善(P〈0.05)。治疗前后及组间血糖差异无统计学意义(P〉0.05),空腹胰岛素水平较治疗前降低.胰岛素敏感性指数较治疗前显著升高。结论缬沙坦可有效降低和改善胰岛素抵抗。
作者 李梅
出处 《海峡药学》 2010年第1期136-137,共2页 Strait Pharmaceutical Journal
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