递增负荷运动对力学信号转导因子的影响效应

Effects of progressive increasing load training on signaling factors of mechanotransduction

按照骨代谢周期设定17周逐级递增负荷运动，观察运动对大鼠部分重要力学信号转导因子的影响及作用效应。发现，大鼠运动13、15及17周组PGE2水平显著低于同期对照组（P〈0．01）；而运动13、15及17周组OPN水平显著高于同期对照组（P〈0．01）；NO仅在运动13周组显著高于同期对照组（P〈0．01）；ALP则在运动4周、11周、15及17周组均显著高于同期对照组（P〈0．01-0．05）。结果表明，所测定的重要力学信号转导因子对运动负荷反应敏感，通过转导过量运动负荷信号，诱导机体产生破骨作用占优势的骨代谢改变，导致骨量降低。

The purpose of this paper was to investigate the results of exercise in some important signaling factors according to bone metabolism cycle. The major results were： PGE2 decreased and OPN increased significantly in T13, T15 and T17 separately （P 〈0.01 ）. NO elevated markedly in T13 （P 〈0.01 ）. ALP rose remarkably in T4, Tll, T15 and T17 （P 〈 0.01 - 0.05 ）. The results indicated that these signaling factors were sensitive to load and transfer the signals of over training load, which may induce osteoclastic bone absorption and bone loss.