摘要
目的探讨肺鳞癌组织中TGF-β1的表达与肺鳞癌临床病理特征的关系。方法采用免疫组织化学Max Vision nTM法检测60例肺鳞癌及癌旁组织存档蜡块组织中TGF-β1的表达情况。结果60例肺鳞癌患者中,TGF-β1阳性20例(33.3%),60例癌旁正常组织阳性10例(16.6%),两者有统计学差异(P<0.05);癌组织中TGF-β1的表达在TNM分期Ⅲ～Ⅳ期组中的阳性表达率高于TNM分期Ⅰ～Ⅱ期组,有转移组高于无转移组,低分化组高于高中分化组(P<0.05);与性别,年龄,肿块大小无明显相关。结论TGF-β1在肺鳞癌组织高表达,且可作为评价肺鳞癌的侵袭和转移有效指标。
Objective To explore the relationship of TGF-β1 expression with clinic pathology character of Human Squamouscell Carinoma of Lung. Methods The expression of TGF-β1 was detected by the method of Immunohistochemistry MaxVision n TM. Results 20 patients presented the masculine expression of TGF-β1 in 60 patients of Human Squamous-cell carinoma of lung. （33.3%）, but only 10 in control group（ 16.6%）.The result shows significantly difference. The expression of TGF-β1 in Ⅲ-IV of TNM staging was higher than that in I - Ⅱ of cancer tissue. Metabasis group was higher than metastases group. Low differentiate group was higher than middle and high group （P〈0.05）, which was not related with gender, age and tumor size.Conclusion The expression of TGF-β1 was high in the tissue of Human Squamous-cell carinoma of lung,which could be the effective index of infestation and metabasis of Human Squamous-cell carinoma of lung.
出处
《江西医药》
CAS
2009年第12期1178-1180,共3页
Jiangxi Medical Journal
