摘要
目的:评价卡培他滨单药治疗晚期原发性肝癌的疗效和不良反应。方法:晚期原发性肝癌20例,给予卡培他滨1000mg/m2,每天2次,共14天,休息7天,每21天为1周期,每2个周期评价疗效。结果:PR 6.7%,SD 56.7%,中位TTP 2.8个月,中位OS 4.2个月。不良反应主要是手足综合征。结论:卡培他滨单药治疗晚期原发性肝癌有效率低,但有较高的肿瘤控制率,不良反应轻。
Objective： To evaluate the efficacy and adverse reactions of capecitabine in advanced primary liver carcinoma （PLC）. Methods： Twenty patients with advanced PLC received oral capecitabine at 1000mg/m^2, twice -daily for 14 days followed by 7 - day rest and repeated in every 21 days intervals and evaluated efficacy in every two cycles. Results： There was no complete response （CR） patients, partial response （PR） was 6.7 %, stabled diseases （SD） was 56.7%. Median time to progression （TTP） was 2.8 months and median overall survival （OS） was 4.2 months. Foot- hand syndrome was the major side effect. Conclusion：Though there was limited efficacy in the treatment of PLC by single capecitabine, there was a high disease control rate （DCR） and the side effect was mild.
出处
《现代肿瘤医学》
CAS
2010年第2期341-342,共2页
Journal of Modern Oncology
关键词
肝肿瘤
化学疗法
卡培他滨
liver neoplasms
chemotherapy
capecitabine
