放疗联合内生场热疗治疗骨转移瘤疗效观察

Study on the effects of radiotherapy combined with local endogenetic thermotherapy in patients with cancer and bone metastases

目的:观察放疗联合内生场热疗治疗骨转移瘤的疗效。方法:50例病理确诊的原发肿瘤且至少一处骨转移患者,分为单纯放疗组25例和放、热疗联合组25例。单纯放疗总剂量30Gy/10次,单次量3Gy,每周5次;放、热疗联合组加内生场热疗,温度控制范围41℃-43℃,每周3-5次,共7-10次,治疗结束后2周评价止痛疗效、活动能力和不良反应。结果:单纯放疗组25例疼痛患者完全缓解12例,部分缓解5例,有效率68.0%;放、热疗联合组24例疼痛患者完全缓解17例,部分缓解5例,有效率91.6%,两组间止痛疗效比较具有显著性差异(P<0.05)。单纯放疗组活动能力改善总有效率为75.0%;放、热疗联合组活动能力改善总有效率为100.0%,两组间比较有显著性差异(P<0.05)。放、热疗联合组较单纯放疗组没有明显增加不良反应。结论:放疗联合内生场热疗治疗是一种治疗骨转移理想的方法,疗效优于单纯放疗。

Objective：To investigate the effects of radiotherapy combined with local endogenetic thermotherapy in treatment of cancer and bone metastases. Methods ： Fifty patients with cancer and bone metastases were divided randomly into 2 groups,25 patients of control group were treated with radiotherapy only, 25 patients of treatment group were treated with radiotherapy combined with local endogenetic thermotherapy. Total radiation dose was 30Gy/10 fractions, single prescription dose was 3.0Gy/fraction,5 fractions per week, treatment group was combined local endogenetic thermotherapy, temperature was controlled in 41℃ - 43 ℃, 3 - 5 times per week for total 7 - 10 times. Response rates of bone pain relief and movement capacity were evaluated after treatment for 2 weeks in two groups. Results： Twelve patients in CR and 5 patients in PR,response rate of bone pain relief was 68.0% in control group of 25 patients with bone pain,17 patients in CR and 5 patients in PR,response rate of bone pain relief was 91.6% in treatment group of 24 patients with bone pain （ P 〈 0.05 ）. Response rates of movement capacity were 75.0% in control group and 100.0% in treatment group（ P 〈0.05）. The side -effects in treatment group was not obviously increased than in control group. Conclusion：Radiotherapy combined with local endogenetic thermotherapy is a good method in treatment of cancer and bone metastases, the effect of treatment group is better than that of radiotherapy only.