甲状腺癌淋巴管生成与转移的研究进展

lymphangiogenesis and metastasis research progress in thyroid carcinoma

淋巴道转移是甲状腺乳头状癌最常见的转移途径,是决定甲状腺乳头状癌分期、选择治疗方案和影响预后的重要因素。淋巴管生成在淋巴道转移过程中起着决定作用,而肿瘤淋巴管生成的分子机制尚未完全明确。研究较多且可以肯定的是VEGF家族在肿瘤淋巴管生成中起重要作用,最近研究发现类肝素酶(heparanase,HPSE)可以诱导VEGF-C的产生进而促发淋巴管生成,进一步深化了淋巴管生成的研究。一些特异性强的淋巴管内皮标记物相继发现,如:VEGFR-3、LYVE-1、Prox1、D2-40等,也为研究淋巴管在肿瘤生物学中的作用提供了必要前提条件。研究甲状腺癌淋巴管生成和转移的分子发生机制,阐明淋巴管生成在甲状腺癌淋巴转移中的作用,将为甲状腺癌的分子靶向治疗和判断预后提供新的理论依据。

Lymph node （LN） metastases is the main way of papillary thyroid carcinoma metastases. It is the most important factor of deciding the staging,treatment options and the prognosis. Lymphangiogenesis plays a decisive role in the course of lymphatic metastasis. VEGF family plays an important role in the tumor lymphangiogenesis , some studies have found that type heparanase （HPSE） can induce VEGF - C and thus trigger the emergence of lymphatic vessel formation. A number of specific lymphatic endothelial markers have been found, such as ： VEGFR - 3, LYVE - 1, Proxl, D2 - 40. Studying the molecular mechanism of tumor metastasis, and lymphangiogenesis in the role of the lymph node metastasis in thyroid carcinoma, will provide a new theoretical basis for the clinical diagnosis and prognosis of throid carcinoma.