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碱性调宁蛋白的研究进展 被引量：7

Advances on Basic Calponin
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摘要 碱性调宁蛋白是一个首先从鸡砂囊和牛主动脉中分离出的相对分子质量为34×103的碱性蛋白。它在平滑肌中特异表达,结合钙调蛋白,肌动蛋白,肌球蛋白,抑制肌球蛋白的ATP酶活性,参与平滑肌收缩、细胞信号转导、维持细胞骨架、抑制细胞增生等。 Basic Calponin is a basic protein first isolated from chicken gizzard and bovine aorta.It is specifically expressed in smooth muscle and binds calmodulin,actin,and tropomyosin.It is able to inhibit the ATPase activity of myosin and is thought to play a role in smooth muscle contraction,signal transduction,cytoskeleton and cellular proliferation.
作者 王书美 张连峰
机构地区 中国医学科学院北京协和医学院实验动物研究所
出处 《中国比较医学杂志》 CAS 2010年第1期57-60,共4页 Chinese Journal of Comparative Medicine
关键词 调宁蛋白 平滑肌 血管病变 Calponin Smooth muscle vascular lesion
分类号 R341 [医药卫生—基础医学]
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参考文献29

  • 1Winder S J, Walsh MP. Calponin: Thin filament-linked regulation of smooth muscle contraction[ J]. Cell Signal, 1993, 5:677 - 686.
  • 2Takahashi K, Hiwada K, Kokubu T. Vascular smooth muscle calponin: a novel troponin T-like protein [ J ]. Hypertension, 1988, 11:620 -626.
  • 3Miano JM, Krahe R, Garcia E, et al. Expression, genomic structure and high resolution mapping to 19p13.2 of the human smooth muscle cell calponin gene[ J]. Gene, 1997, 197:215 - 224.
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  • 5Goodman A, Goode BL, Matsudaira P, et al. The saccharomyces cerevisiae calponin/transgelin homolog Scpl functions with fimbrin to regulate stability and organization of the actin cytoskeleton[ J]. Mol Biol Cell, 2003, 14:2617 - 2629.
  • 6Morgan KG, Gangpadhyay SS. Signal transduction in smooth muscle: Invited review: Cross-bridge regulation by thin filamentassociated proteins[J]. J Appl Physiol, 2001, 91:953 -962.
  • 7Gimona M, Kaverina I, Resch GP, et al. Calponin repeats regulate actin filament stability and formation of podosomes in smooth muscle cells[ J]. Mol Bio cell, 2003, 14:2482 - 2491.
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  • 9Takahashi K, Hiwada K, Kokubu T. Isolation and characterization of a 34, 000-dalton calmodulin- and Factinbinding protein from chicken gizzard smooth muscle [ J ]. Biocbem Biophys Res Commun, 1986, 141:20 - 26.
  • 10Childs TJ, Watson MH, Novy RE, et al. Calponin and tropomyosin interactions [ J ]. Bioehem Biophys Acta, 1992, 1121:41 -46.

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中国比较医学杂志
2010年 第1期

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