外源性干细胞移植治疗缺血性脑损伤
被引量:1
Allogeneic stem cell transplantation in the treatment of stroke-induced brain damage
摘要
全世界脑缺血性卒中患者大约有上千万例,每年都有近百万例新增患者。约半数患者都会遗留不同程度的神经功能缺失。干细胞移植为脑缺血性卒中患者提供了新的治疗方向。神经干细胞移植治疗脑缺血理想目标包括:(1)缺血区受损神经元能被同型神经元替代;(2)诱导局部血管再生使移植神经干细胞长期存活;(3)移植神经元能与周围细胞建立突触联系;(4)胶质细胞辅助移植神经元形成髓鞘。
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2010年第2期208-210,共3页
Chinese Journal of Neuromedicine
基金
基金项目:黑龙江省教育厅资助项目(10511059、10553062)
关键词
干细胞
细胞移植
卒中
Stem cell
Cell transplantation
Stroke
参考文献24
-
1Williams BP, Park JK, Alberta JA, et al. A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells[J]. Neuron, 1997, 18(4): 553-562.
-
2Galli R, Pagano SF, Gritti A, et al. Regulation of neuronal differentiation in human CNS stem cell progeny by leukemia inhibitory factor[J]. Dev Neurosci, 2000, 22(1-2): 86-95.
-
3Sun Y, Nadal-Vicens M, Misono S, et al. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms[J]. Cell, 2001, 104(3): 365-376.
-
4Morrison S J, Perez SE, Qiao Z, et al. Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural CREST stem cells[J]. Cell, 2000, 101(5): 499-510.
-
5Fan G, Martinowich K, Chin MH, et al. DNA methylation controls the timing of astrogliogenesis through regulation of jak-stat signaling[J]. Development, 2005, 132(15): 3345-3356.
-
6Lukaszewicz A, Savatier P, Cortay V, et al. Contrasting effects of basic fibroblast growth factor and neurotrophin 3 on cell cycle kinetics of mouse cortical stem cells[J]. J Neurosci, 2002, 22(15): 6610-6622.
-
7Kim M, Morshead CM. Distinct populations of forebrain neural stem and progenitor cells can be isolated using side-population analysis[J]. J Neurosci, 2003, 23(33): 10703-10709.
-
8Carmichael S. Cellular and molecular mechanisms of neural repair after stroke:making waves[J]. Ann Neurol, 2006, 59(5): 735-742.
-
9Zhang C, Li Y, Chen J, et al. Bone marrow stromal cells upregulate expression of bone morphogenetic proteins 2 and 4, gap junction protein eonnexin-43 and synaptophysin after stroke in rats [J]. Neuroscience, 2006, 141(2): 687-695.
-
10Manoonkitiwongsa PS, Schultz RL, McCreery DB, et al. Neuroprotection of ischemic brain by vascular endothelial growth factor is critically dependent on proper dosage and may be compromised by angiogenesis [J]. J Cereb Blood Flow Metab, 2004, 24(6): 693-702.
二级参考文献27
-
1Lossi L, Merighi A. In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS [J]. Prog Neurobiol,2003, 69(5): 287-312.
-
2Sommer L, Rao M. Neural stem cells and regulation of cell number[J]. Prog Neurobiol, 2002, 66(1): 1-18.
-
3Lin HJ, Wang X, Shaffer KM, et al. Characterization of H2O2-induced acute apoptosis in cultured neural stem/progenitor cells[J].FEBS Lett, 2004, 570(1-3): 102-106.
-
4Lasky JL, Wu H. Notch signaling, brain development, and human disease[J]. Podiatr Res, 2005, 57(5 Pt 2): 104R-109R.
-
5Ille F, Sommer L. Wnt signaling: multiple functions in neural development[J]. Cell Mol Life Sci, 2005, 62(10): 1100-1108.
-
6Israel A, Kroemer G. NF-KB in life-death decisions-an introduction[J]. Cell Death Differ, 2006, 13(5): 685-686.
-
7Sanchez-Carbente MR, Castro-Obregan S, Covarrubias L, et al.Motoneuronal death during spiaal cord development is mediated by oxidative stress[J]. Cell Death Differ, 2005, 12(1): 279-291.
-
8Yuan J, Lipinski M, Degterev A. Diversity in the mechanisms of neuronal cell death[J]. Neuron, 2003, 40(2): 401-413.
-
9Hoshino M, Qi ML, Yoshimura N, et al. Transcriptional repression induces a slowly progressive atypical neuronal death associated with changes of YAP isoforms and p73[J]. J Cell Biol, 2006, 172(4): 589-604.
-
10Li J, Spletter ML, Johnson DA, et al. Rotenone-induced caspase 9/3-independent and -dependent cell death in undifferentiated and differentiated human neural stem cells [J]. J Neurochem, 2005, 92(3): 462-476.
同被引文献23
-
1王红祥,李宾公,邵诗颖,赵智刚,唐晓琼,邹萍.内皮祖细胞移植治疗大鼠急性心肌梗死的实验研究[J].中华老年心脑血管病杂志,2006,8(9):628-631. 被引量:3
-
2马占龙,滕皋军,麦筱莉,居胜红,邓刚,孙军辉,张洪英,余辉,李国昭.血管内皮祖细胞靶向损伤血管内皮磁共振成像的实验研究[J].中华医学杂志,2007,87(10):679-684. 被引量:6
-
3Isner J M, Asahara T. Angiogenesis and vaseulogenesis as therapeu- tic strategies for postnatal neovascularization [ J ]. J Clin Invest, 1999,103(9) :1231 -6.
-
4Asahara T, Murohara T, Sullivan A, et al. Isolation of putative pro- genitor endothelial cells for angiogenesis [ J ]. Science, 1997,275 (5302) :964 -7.
-
5Ii M, Nishimura H, Iwakura A, et al. Endothelial progenitor cells are rapidly recruited to myocardium and mediate protective effect of ischemic preconditioning via "imported" nitric oxide synthase ac- tivity [ J ]. Circulation ,2005,111 (9) : 1114 - 20.
-
6Rouhl R P, van Oostenbrugge R J, Damoiseaux J, et al. Endothelial progenitor cell research in stroke : a potential shift in pathophysio- logical and therapeutical concepts[ J ]. Stroke, 2008,39 ( 7 ) : 2158 -65.
-
7Isner J M, Kalka C, Kawamoto A, et al. Bone marrow as a source of endothelial cells for natural and iatrogenic vascular repair[ J]. Ann N Y Acad Sci,2001,953 :75 -84.
-
8Aoki M, Yasutake M, Murohara T. Derivation of functional endothe- lial progenitor cells from human umbilical cord blood mononuelear cells isolated by a novel cell filtration device [ J ]. Stem Ceils, 2004,22(6) :994 - 1002.
-
9Gehling U M, Ergiin S, Schumacher U, et al. In vitro differentiation of endothelial ceils from AC133-positive progenitor cells [ J ]. Blood,2000,95 ( l0 ) :3106 - 12.
-
10I-Iristov M, Erl W, Weber P C. Endothelial progenitor cells : mobili- zation, differentiation, and homing [ J 1. Arterioscler Thromb Vasc Biol,2003,23 (7) : 1185 - 9.
-
1束汉生,曾水林.帕金森病移植神经元凋亡的研究进展[J].立体定向和功能性神经外科杂志,2000,13(4):238-241.
-
2张彬,孙晓江.脑出血后脑损伤机制的研究进展[J].中国老年学杂志,2007,27(13):1323-1325. 被引量:6
-
3刘卫平,肖波,杨晓苏,李蜀渝,彭仁罗,王蓉,张贺.难治性癫痫的MRI改变探讨[J].卒中与神经疾病,2003,10(4):195-197. 被引量:3
-
4李菁.缺血性脑血管病神经保护治疗的研究进展[J].临床药物治疗杂志,2005,3(6):16-20.
-
5朱琼,徐亚丽,刘政.神经干细胞治疗阿尔茨海默病的研究进展[J].重庆医学,2016,45(30):4286-4288. 被引量:1
-
6姜智南,张天锡,杨践.免疫组化法观察兔脑缺血灶内移植神经元的变化[J].中国神经精神疾病杂志,1992,18(3):137-139. 被引量:1
-
7顾诗渊,黄流清.额颞叶痴呆9例报道附文献回顾[J].卒中与神经疾病,2013,20(4):236-239. 被引量:1
-
8杨东波,蒋传路,李永利.脑缺血卒中后内源性神经再生的调节机制[J].立体定向和功能性神经外科杂志,2009,22(4):246-249.
-
9涂雪松.干细胞移植治疗缺血性脑血管病实验研究进展[J].中国脑血管病杂志,2014,11(8):440-445. 被引量:6
-
10李博,王苑宇,焦保华.脑出血的损伤机制及治疗方向[J].河北医科大学学报,2013,34(11):1481-1484. 被引量:19