食管鳞形细胞癌组织中CXCR4和血管内皮生长因子表达的相关性研究

CXCR4 and vascular endothelial growth factor expressions in esophageal squamous cell cancer and their correlations

目的探讨CXCR4和血管内皮生长因子(vascular endothelial growth factor,VEGF)在食管癌组织中表达的相关性及其与患者临床病理特征的关系。方法收集2005年于我院行根治性手术的127例胸段食管癌腊块标本,利用免疫组化技术检测食管癌组织中CXCR4和VEGF的表达,根据染色面积和染色强弱判断两者的表达水平。结果CXCR4和VEGF表达阳性率分别为88.2%和79.5%。CXCR4的表达与肿瘤细胞分化、大小、浸润深度、区域淋巴结转移以及TNM分期具有相关性(P<0.05)。VEGF的表达和肿瘤浸润深度、TNM分期及细胞分化具有相关性。此外,CXCR4和VEGF表达亦具有显著相关性(P<0.01)。结论CXCR4和VEGF表达与食管癌的临床病理特征有明显相关性;食管癌细胞中CXCR4和VEGF的表达之间可能存在潜在的关联。

Objective To investigate the correlations of the expressions of CXCR4 and vascular endothelial growth factor（VEGF） in esophageal cancer and their associations with patients＇ clinicopathological features.Methods The paraffin-embedded samples of 127 patients with esophageal cancer treated by thoracic surgery in Zhongshan Hospital in 2005 were collected.The CXCR4 and VEGF expressions in esophageal cancer tissues were detected with immunohistochemical technique.The immunostaining was evaluated according to the staining area and intensity. Results The overall expression rate was 88.2% and 79.5%,respectively.CXCR4 expression was significantly associated with tumor grade,size,tumor depth,regional lymph node metastasis and TNM stage（P0.05）;VEGF expression was significantly associated with tumor depth,TNM stage and tumor grade.In addition,there were significant correlations between CXCR4 and VEGF（P0.01）. Conclusions There was significant association between CXCR4,VEGF expressions and clinicopathological features of esophageal cancer.There might be some potential correlation between CXCR4 and VEGF expression in esophageal cancer.