摘要
目的探讨上海地区今年甲型H1N1流感确诊病例的临床特点。方法2009年5月24日~2009年6月15日上海市(复旦大学附属)公共卫生临床中心收治的甲型H1N1流感最初10例确诊病例的流行病学及临床资料。结果甲型H1N1流感病例的临床特点:①10例患者平均年龄为30.1岁(18~47岁);全部为输入性病例,感染地区为美国(70%),澳大利亚(30%)。②起病急、发病到住院时间平均为2.7天;潜伏期平均为4.3天;首发症状多为发热(70%),大多数为中低热、持续1~4天。主要症状和体征为发热(100%)、咳嗽(80%)、咽痛(50%),咽部充血(100%)和扁桃体肿大(50%)等,症状持续时间为1~7天。少数患者可出现病毒性肺炎(20%),无重症病例。③WBC多数正常,没有显著的中性粒细胞和淋巴细胞计数上升或下降;C反应蛋白升高和CD4+下降比较常见。④全部病例给予奥司他韦治疗,流感病毒转阴时间1~6天,中位时间4天。结论上海出现的甲型H1N1流感能在人与人之间传播,感染者大多表现出轻微的症状,很快痊愈。
Objective To summarize the epidemiology and clinical features of new 1 influenza A ( H1N1), and to analyze characteristics of the first ten adult cases in Shanghai. Methods Retrospective analysis was conducted of epidemiology and clinical data of 10 cases with new influenza A ( H1 N1 ) From May 24 to June 15,2009. Results Clinical features of 10 cases of new influenza A ( H1N1 ) :(1) Mean age was 30. 1 ( range 18 - 47 ) years; They were travellers from United States (70%) or Australia (30%) ; (2) Acute onset, They developed symptoms within a mean of 2.7 days of arrival in hospital, incubation period of 4.3 days (2 to 6 days) ; the first symptoms were fever (70%), mostly in low-heat, last for 1 to 4 days. The main symptoms and signs were fever (100%), cough (80%), pharyngodynia ( 50% ), pharyngeal hyperemia ( 100% ), tansillar swelling (50%) ; a small number of patients might be with viral pneumonia (20%), non-severe cases. (3) WBC were most normal, no significant neutrephil and lymphocyte count upward or downward, elevated serum C-reactive protein and decreased CD4 is more common;(4) Osehamivir in treatment was under the premise of H1 N1 negative patients from 1 to 6 days, with a median time of 4 days. Conclusion New Influenza A ( H1 N1 ) can spread from person to person. The prevalence of the infection period converse a wide range of flu symptoms. The patients recover quickly in Shanghai.
出处
《临床肺科杂志》
2010年第3期303-304,307,共3页
Journal of Clinical Pulmonary Medicine