摘要
目的观察甲基泼尼松龙冲击疗法(MPPT)治疗Balo病的近期及远期临床疗效。方法18例Balo病患者,均经过临床及头颅MRI有特异性表现所明确诊断。成人采用甲基泼尼松龙(MP)1000mg/d,儿童20mg·kg-1·d-1)加入5%葡萄糖1000ml溶液内静脉缓慢滴注,连用3d为1疗程,每月1疗程,共3个疗程。结果近期临床疗效(3个月内)为:显效12例(66.7%),有效4例(22.2%),无效2例(11.1%);临床观察6个月、1年、2年和3年时临床缓解率均为72.2%。结论MPPT治疗Balo病3个月~3年长期缓解率较高,6月内无缓解的预后差,有疗效的患者采用小剂量泼尼松龙可以取得较长的缓解时间,有一定的临床实用和推广价值。
Objective To evaluate the therapeutic effect of Balo disease treated by methylprednisolone pulse therapy (MPPT) including the followed-up of recent clinical efficacy and long-term clinical efficacy. Methods Eighteen patients of Balo disease used MPPT and were diagnosed to undergo a brain MRI and clinical performance of a specific. The adult dose used was methylprednisolone(MP) 1 000 mg/ d, and the children dose was 20mg/(kg·d) by adding 5% glucose solution with 1 000 ml slowly intravenous drip. Three days of continuous use was a course of treatment per month, a total of three treatments. Results The recent curative effect (within 3 months after treatment) was as follows: twelve eases (66.7%) acquired a significant effect, four cases (22.2%) patients'conditions were improved, and two cases (11.1%) had no effect. The rate increased to 72.2% after retesting at 6 months, 1 year, 2 years and 3 years. Conclusion Most Balo disease patients treated with MPPT had acquired perfectly curative effect from 6 months to 3 years after treatment. However, some did not acquire a good effect in six months and became worse. The patients with therapeutic use of low-dose prednisone can have a longer remission time. This method has some clinical utility value and should be promoted as useful.
出处
《安徽医学》
2010年第1期44-46,共3页
Anhui Medical Journal