虫草素类似物2’-脱氧腺苷脂质体的制备及表征

The Preparation and Characterization of 2'-deoxyadenosine Liposome-an Analogue of Cordycepin

虫草素具有多种生物活性,通过与新型药物载体脂质体结合,可解决其临床中的脱氨基作用。2'-脱氧腺苷是虫草素的结构类似物,易制备,具有和虫草素相同的紫外最大吸收波长(259nm),是一种优良的虫草素替代品,研究2'-脱氧腺苷脂质体可为虫草素脂质体的研究提供重要的参考。本文采用逆相蒸发法制得球形、粒径170～350nm、包封率为45%、稳定性良好的2'-脱氧腺苷脂质体。为虫草素脂质体研究提供基础数据。

Cordycepin possessed a wide range of biological activities. Its deactivation in clinic can be resolved by combining it with liposome. 2＇ - deoxyadenosine, an analogue of cordycepin, was easy to prepare and had the same maximal ultraviolet absorption band as cordycepin（259nm） , so it was an excellent substitute for eordycepin. 2＇-deoxyadenosine liposome was investigated which could provide references for the cordycepin liposome research. In the study, 2＇ - deoxyadenosine liposome was prepared by reverse -phase evaporation successfully. It was ball -shaped, the particle size was 170 -350nm, the entrapment efficiency was 45% , and the liposome also had a good stability. This provided the necessary basic data for the cordycepin liposome research.