含1-[二-(4-氟苯)甲基]哌嗪均三氮唑环的Mannich碱的合成及表征

Synthesis and characterization of 1-[bi-(4-fluorophenyl)-methyl]piperazine substituted 1,2,4-triazole Mannich base

微波辐射下,在冰醋酸中,3-甲基-4-氨基-1,2,4-三氮唑-5-硫酮1与芳香醛经微波辐射制得相应的中间体Schiff碱2(a^j),然后中间体2与1-[二-(4-氟苯)甲基]哌嗪于室温反应制得10个新的Mannich碱3(a^j).合成的10个目标化合物通过熔点测定和质谱、红外光谱、核磁共振氢谱分析、元素分析对其结构进行确证。

Ten Mannich bases 3 （ a -j） were synthesized in this paper. Firstly under microwave irradiation conditions, 4,5-dihydro- 3-methyl-4-amino-1,2 ,4- triazole -5-thione 1 reacted with substituted benzaldehyde in acetic acid to form the key intermediate 2（ a-j ）. Then the target compounds 3 （ a-j ） were synthesized by the condensation between 1 - [ bi- （ 4 -fluorophenyl） -methyl ] piperazine and the intermediates 2 （a - j ）in ethanol at room temperature. The structures of target compounds 3 （a - j ）were confirmed by IR, 1HNMR, MS spectra and elemental analysis.