刺五加茎叶化学成分的分离与鉴定

Isolation and identification of chemical constituents from stems and leaves of Acanthopanax senticosus (Rupr.et Maxim.) Harms

目的研究五加科五加属植物刺五加（Acanthopanax senticosus（Rupr．et Maxim．）Harms）茎叶中的化学成分。方法采用反复硅胶色谱法分离纯化，通过理化常数测定和谱学分析鉴定其化学结构。结果分离得到7个化合物，分别鉴定为丁香苷（sydgin，1）、刺五加苷B，（eleutheroside B1，2）、刺五加苷D（eleutheroside D，3）、甘露醇（mannitol，4）、丁香醛（syringaldehyde，5）、2，6-二甲氧基苯甲酸苄酯（2，6-dimethoxybenzoic acid phenylmethyl ester，6）、salvadoraside（7）。结论化合物5-7为首次从五加属植物中分离得到的已知化合物。

Objective To study the chemical constituents of the stems and leaves of Acanthopanax senticosus （ Rupr. et Maxim. ） Harms. Methods The compounds were isolated by chromatography on silica gel column and identified by physical-chemical properties and spectral analysis. Results Seven compounds were obtained and identified as syrigin （ 1 ）, eleutheroside B1 （2）, eleutheroside D （3）, mannitol （4）, syringaldehyde （5） ,2, 6-dimethoxybenzoic acid phenylmethyl ester（6）, salvadoraside （7）. Conclusions Compounds 5- 7 are isolated from this genus for the first time.