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法呢醇X受体激动剂研究进展

Progress on the development of farnesoid X receptor agonists
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摘要 法呢醇X受体(FXR)通过调节胆汁酸的合成、分泌和吸收来调节胆汁酸的代谢和稳态。法呢醇X受体激动剂有望成为治疗胆汁酸代谢相关疾病的新型药物。该文对近年来报道的法呢醇X受体激动剂进行简要综述。 Farnesoid X receptor（ FXR）, a key controller of bile acid homeostasis and metabolism, regulates bile acid synthesis, secretion, and absorption. FXR agonists are expected to be new kind of therapeutic drugs for diseases related to bile acid metabolism. The progress on the research of FXR agonists in recent years was summarized.
作者 贾薇 李伟 宫平
机构地区 沈阳药科大学制药工程学院
出处 《中国药物化学杂志》 CAS CSCD 2010年第1期64-69,共6页 Chinese Journal of Medicinal Chemistry
关键词 法呢醇X受体 激动剂 鹅脱氧胆酸 6-ECDCA WAY-362450 farnesoid X receptor agonist CDCA 6-ECDCA WAY-362450
分类号 R96 [医药卫生—药理学]
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参考文献21

  • 1KUIPERS F,STROEVE J H M, CARON S,et al. Bile acids, famesoid X receptor, atherosclerosis and metabolic control [ J ]. Curr Opin Lipidol, 2007,18 (3) :289 -297.
  • 2FIORUCCI S,RIZZO G,DONINI A,et al. Targeting farnesoid X receptor for liver and metabolic disorders [ J ]. Trends Mol Med,2007,13 (7) :298 - 309.
  • 3MODICA S, MOSCHETTA A. Nuclear bile acid receptor FXR as pharmacological target:Are we there yet? [ J]. FEBS Lett,2006,580(23) :5492 - 5499.
  • 4CLAUDEL T, STURM E, KUIPERS F, et al. The farnesoid X receptor:a novel drug target? [J]. Expert Opin Investig Drugs ,2004,13 (9) : 1135 - 1148.
  • 5PELLICCIARI R, COSTANTINO G, FIORUCCI S. Famesoid X receptor:from structure to potential clinical applications [ J ]. J Med Chem, 2005,48 ( 17 ) : 5383 - 5403.
  • 6PARKS D J,BLANCHARD S G,BLEDSOE R K,et al. Bile acids:natural ligands for an orphan nuclear receptor[ J ]. Science, 1999, 284 ( 5418 ) : 1365 - 1368.
  • 7MAKISHIMA M, OKAMOTO A Y, REPA J J, et al. Identification of a nuclear receptor for bile acids[J]. Science, 1999,284(5418) : 1362 - 1365.
  • 8FUJINO T, UNE M, IMANAKA T, et al. Structure- activity relationship of bile acids and bile acid analogs in regard to FXR activation[ J]. J Lipid Res, 2004,45( 1 ) : 132 - 138.
  • 9PELLICCIARI R,FIORUCCI S,CAMAIONI E,et al. 6 alpha-Ethyl-chenodeoxycholic acid ( 6-ECDCA ), a potent and selective FXR agonist endowed with anticholestatic activity [ J ]. J Med Chem, 2002,45 (17) :3569 -3572.
  • 10PELLICCIARI R, COSTANTINO G, CAMAIONI E,et al. Bile acid derivatives as ligands of the famesoid X receptor. Synthesis, evaluation, and structure- activity relationship of a series of body and side chain modified analogues of chenodcoxycholic acid [J]. J Med Chem,2004,47(18) :4559- 4569.
中国药物化学杂志
2010年 第1期

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