芳香化酶抑制剂的研究进展

Recent development in the studies on aromatase inhibitors

芳香化酶是雌激素生物合成过程中的一个关键酶,抑制芳香化酶的活性就可以抑制雌激素的生成,从而减少绝经后妇女乳腺癌等疾病的发病率。以芳香化酶为靶标的研究一直都是抑制剂研究的热点,目前已有多个芳香化酶抑制剂进入临床试验阶段或已上市,该文对近年来芳香化酶抑制剂的研究进行综述。

Aromatase is the key enzyme in estrogen biosynthesis. Aromatase inhibitors, by means of inhibiting the process of estrogen biosynthesis, are proved to be effective in breast cancer and other diseases occured in postmenopausal women. Therefore, scientific research have been carried out on new aromatase inhibitors, some of which have been taken into clinical trials or market. Recent development of aromatase inhibitors were reviewed.