药源性铅中毒的临床分析

Clinical Analysis of Drug-induced Lead Poisoning

背景：药源性铅中毒临床表现无特异性，且中毒原因隐匿，故在综合性医院易被误诊、误治。目的：提高综合性医院临床医师对药源性铅中毒的诊断水平。方法：分析1984年1月～2008年12月北京协和医院7例铅中毒患者的各项临床资料。结果：本组3例患者为职业性铅中毒，其余4例药源性铅中毒患者均服用过治疗银屑病的中药偏方。7例患者均出现消化系统症状和贫血，经驱铅治疗后症状消失。结论：临床上对不明原因腹痛或不完全性肠梗阻伴贫血的患者，特别是曾有中药服用史的患者，应警惕药源性铅中毒的可能。

Background： Drug-induced lead poisoning is likely to be misdiagnosed and mistreated in general hospital because the symptoms are generally nonspeeifie and the eauses are oecuh. Aims： To improve the ability of clinicians in general hospital to diagnose drug-induced lead poisoning. Methods： The clinical data of 7 patients with lead poisoning from January 1984 to December 2008 diagnosed in PUMC hospital were retrospectively analyzed. Results： Occupational lead poisoning was found in 3 patients and drug-indueed in the other four patients who had taken folk herb prescriptions for treating psoriasis. Symptoms of digestive system and anemia were the manifestations in these 7 patients, which disappeared after chelating therapy. Conclusions： Drug-induced lead poisoning should be suspected in patients with unexplained abdominal pain or incomplete intestinal obstruction complicated with anemia, especially in patients with a history of taking folk herb prescriptions.