Survivin和Ki-67在皮肤鳞癌和基底细胞上皮瘤的表达及相关性分析

The Expression and Correlational Analysis of Survivin and Ki-67 in Tissues of Squamous Cell Carcinoma and Basal Cell Epithelioma

目的观察Survivin和Ki-67在皮肤鳞癌(SCC)及基底细胞上皮瘤(BCE)的表达,并探讨其意义。方法采用免疫组化法检测15例皮肤SCC,20例BCE中Survivin和Ki-67的表达情况,并以16份整形手术切除的正常组织作为对照。结果Survivin在皮肤SCC和BCE中的阳性表达率显著高于正常对照组,且在皮肤SCC的阳性表达率也显著高于BCE,差异均有统计学意义(P均<0.05)。Ki-67在皮肤SCC和BCE中的阳性表达也显著高于正常对照组(P<0.05),但在皮肤SCC和BCE组织中的表达比较,差异无统计学意义(P>0.05)。皮肤SCC和BCE组织中Survivin和Ki-67的阳性细胞表达呈正相关(r=0.77,P<0.05)。结论Survivin与Ki-67在皮肤SCC和BCE组织中的表达均升高,且呈正相关,提示两基因有可能共同参与肿瘤的发生和发展。

Objective To observe the expression and effect of Survivin, Ki-67 in lesions of squmaous cell carcinoma （SCC） and basal cell epithelioma （BCE）. Methods The expression of Survivin, Ki-67 in SCC and BCC were detected by immunohistochemical method. 16 normal tissue from plastic surgery of as control. Results The positive expression rate of Survivin was higher in SCC and BCE than that in normal skin with a statistically significant differences （all P 〈 0.05）. The positive expression of Survivin was higher in SCC than that in BCE with a statistically significant difference （ P 〈 0.05 ）. The positive expression of Ki-67 was higher in SCC and BCE than that in normal skin with a statistically significant difference （ P 〈 0.05）, But there was no significant difference between SCC and BCE （ P 〉 0.05）. There was a positive correlation between Survivin and Ki-67 in SCC and BCE （r = 0. 77, P 〈 0. 05 ）. Conclusions The expression of Survivin and Ki- 67 both in lesion of SCC and BCE were higher, which indicated that two genes might contribute to the development of tumors.