308nm准分子激光联合0.1%他克莫司软膏治疗寻常性银屑病疗效观察

Clinical Efficacy of 0.1% Topical Tacrolimus Ointment Combined with 308nm Excimer Laser in Treatment of Psoriasis Vulgaris

目的探讨308nm准分子激光联合0.1%他克莫司软膏治疗寻常性银屑病的临床疗效。方法所有参加研究的患者均接受308nm准分子激光照射2次/w,共6周,且皮损处外搽0.1%他克莫司软膏,早、晚各1次,疗程6周。每2周根据皮损进行治疗前及治疗后的PASI评分比较。结果308nm准分子激光照射平均次数为7.31(5～11)次,外搽0.1%他克莫司软膏平均次数为79.2(69～91)次,治疗6周结束后平均PASI评分为3.15(3.34±1.98),治疗前平均PASI评分为15.31(17.59±3.67),有效率81.40%,治疗前、后2次PASI评分比较,差异有统计学意义(P<0.05)。不良反应轻微,发生率为20.93%。结论308nm准分子激光联合0.1%他克莫司软膏治疗寻常性银屑病疗效好,不良反应少。

Objective To explore the efficacy and safety of taerolimus combined with 308nm excimer laser in treating psoriasis vulgaris. Methods All patients were treated with 308nm excimer laser （twice a week） ,and topical tacrolimus ointment twice a day（ moring and night） on target lesions for 6 weeks. PASI scoring were used to evaluate before and after treatment once two weeks. Results Number of treatment with 308rim excimer laser was 7.31 （5 - 11 ）, and that of 0.1% topical tacrolimus ointment was 79.2 （69 - 91 ）, the average PASI score after 6-week-treatment was 3.15 （3.34 ± 1.98 ）, while before treatment was 15.31 （ 17.59 ± 3.67 ）, and the effective rate was 81.40%. There is significant differences （ P 〈 0.05 ）. During treatment, the rate of adverse reactions was 20.93% and not severe. Conclusion The treatment of psoriasis vulgaris with combined 308rim excimer laser and 0.1% topical tacrolimus ointment showed good efficacy with little adverse reactions.