声触诊组织成像量化技术无创评价慢性肝病肝纤维化程度的初步临床研究

Initial clinical study of virtual touch quantification for evaluation of hepatic fibrosis of chronic liver disease

目的探讨声触诊组织成像量化（VTQ）技术无创评价慢性肝病患者肝纤维化程度的临床价值。方法应用VTQ技术对115例拟行超声引导下肝穿刺活检慢性肝病患者和80例健康成人行肝检查，并对检查结果进行对比分析。结果慢性肝病组和健康组之间VTQ值差异有显著统计学意义（P=0．0000）；慢性肝病患者不同病理分期间的VTQ值除S0与S1外，其他病理分期间差异均有统计学意义（P=0．0212或P=0．0000）；将S0-S2合并为轻度肝纤维化，S3-S4合并为中-重度肝纤维化，用ROC曲线分析阈值，当VTQ值≥1．4m／s时，诊断中-重度肝纤维化的敏感度和特异度分别为85．4％和64．7％。结论VTQ检查作为无创、量化的检查手段，可用来评价慢性肝病患者的肝纤维化程度。

Objective To explore the clinical value of virtual touch quantification （VTQ） technique in assessing the hepatic fibrosis. Methods A total of 115 inpatients with chronic liver disease receiving liver biopsy were enrolled in this study,all patients liver tissue was checked by VTQ technique,and the results were compared with those of the control group including 80 healthy subjects. Results VTQ value was significantly different between the two groups （ P = 0. 001）0）. The VTQ value among different degree of hepatic fibrosis but between SO and S1 had statistical signifieances （ P = 0. 0212, P = 0. 01100）. ROC curve displayed that VTQ value of 1.4 m/s could be used to diagnose middle-high-grade liver fibrosis,the sensitivity and specificity were 85.4% and 64.7%, respectively. Conclusions VTQ can be used as a noninvasive and effective means for assessing the degree of hepatic fibrosis.