摘要
As an important nucleus of basal ganglia,globus pallidus was concerned to involve in the neural mechanism of Parkins’s disease (PD). Previous studies of PD patients and animal model indicate that neurotransmitters and receptors are changed in globus pallidus neurons,the balance between inhibition and excitation is broken in the output nuclei of basal ganglia,and globus pallidus neurons display bursting and oscillatory discharge,the synchronous tendency of neighboring neurons enhances. These neurophysiological changes are associated with PD symptoms,such as bradykinesia,rigidity and tremor,which reflects that globus pallidus plays an important role in the process of PD. In the present paper,the recent advances in pathophysiology in globus pallidus,its clinical application in treatment of Parkinson’s disease,and the study direction in the future are reviewed.
As an important nucleus of basal ganglia, globus pallidus was concerned to involve in the neural mechanism of Parkins＇s disease （PD）. Previous studies of PD patients and animal model indicate that neurotransmitters and receptors are changed in globus pallidus neurons, the balance between inhibition and excitation is broken in the output nuelei of basal ganglia, and globus pallidus neurons display bursting and oscillatory, discharge, the synchronous tendency of neighboring neurons enhances. These neurophysiological changes are associated with PD symptoms, such as bradykinesia, rigidity and tremor, which reflects that globus pallidus plays an important role in the process of PD. In the present paper, the recent advances in pathophysiology in globus pallidus, its clinical application in treatment of Parkinson＇s disease, and the study direction in the future are reviewed.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2010年第2期396-400,共5页
Chinese Journal of Pathophysiology
关键词
帕金森病
苍白球
多巴胺
谷氨酸
Parkinson disease
Globus pallidus
Dopamine
Glutamic acid
