特发性肺纤维化患者血硫化氢水平下降

Serum hydrogen sulfide reduces in idiopathic pulmonary fibrosis patients

目的探讨特发性肺纤维化(IPF)患者疾病过程中内源性硫化氢(H2S)的变化和意义,及其与IPF疾病严重程度的关系。方法将研究对象分为IPF组和对照组,检测各组血浆H2S含量。对IPF组行动脉血氧分压、红细胞沉降率(ESR)、C反应蛋白(CRP)、乳酸脱氢酶(LDH)、肺功能及高分辨CT(HRCT)检查;测定IPF组患者在症状急性加重和缓解时血浆H2S含量。结果(1)IPF组血浆H2S含量明显低于对照组(P<0.01);(2)IPF组血浆H2S含量在急性加重时明显高于症状缓解时(P<0.01);(3)随影像学病变进展,IPF组患者血浆H2S含量无明显下降。结论内源性H2S可能参与了IPF的疾病过程,可能与疾病的严重程度相关。

Objective To explore the effect of endogenous H2S in idiopathic pulmonary fibrosis（IPF） patients, and its relationship with the severity of IPF. Methods Plasma H2 S in 27 patients with IPF （IPF group）and 28 healthy people （control group） were tested. PaO2, ESR, CRP, LDH, HRCT and pulmonary function in IPF group were tested to evaluate the severity of the disease at the same time. Then the concentrations of H2S in aggravating and palliative period in IPF group were observed. Results （ 1 ） Compared with the control group, the concentration of plasma H2S in IPF group was significantly redueed（P 〈0. 01 ）. （2）The concentration of HES in aggravating period was higher than that during palliative period （P 〈 0. 01 ）. （3） With the progress of HRCT, there was a descending trend of plasma H2S （P 〉 0. 05 ）. Conclusion Endogenous H2S was probably involved in the course of IPF, and was associated with the progress of the disease.