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转导特定基因重编程体细胞为多能干细胞 被引量：2

Induction of pluripotent stem cells from somatic cells by reprogramming with defined genes
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摘要 通过转导特定基因将体细胞重编程可获得诱导性多能干细胞,这种建系方法标志着干细胞实验技术的重大突破。本文综述该细胞建立、鉴定及最新进展。 Differentiated cells can be induced into pluripotent stem cell by reprogramming with defined fators. The new method of stem cell technology marks a major breathrough. This paper reviews the establishment, identification and research progress about induction of pluripotent stem cell.
作者 林真 沈晓丽
机构地区 福建医科大学省立临床医学院心血管病重点实验室
出处 《基础医学与临床》 CSCD 北大核心 2010年第2期206-208,共3页 Basic and Clinical Medicine
基金 福建省科技厅项目(2005Q006 2009Y0009)
关键词 诱导性多能干细胞 诱导 重编程 induced pluripoteut stem cell induction reprogramming
分类号 Q813.5 [生物学—生物工程]
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参考文献12

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同被引文献13

  • 1王晶,李亚里,彭红梅.胚胎干细胞移植治疗帕金森病的研究进展[J].基础医学与临床,2007,27(8):944-947. 被引量：2
  • 2Park IH, Arora N, Huo HG, et al. Disease-specific in- duced pluripotent stem (iPS) cells [ J ]. Cell, 2008, 134 : 877 - 886.
  • 3Freund C, Mummery CL. Prospects for pluripotent stem cell-derived cardiomyocytes in cardiac cell therapy and as disease models[J]. J. Cell Biochem, 2009, 107:592 - 599.
  • 4Takahashi K, Tanabe K, Ohnuki M, et al. Induction of plu- ripotent stem ells from adult human fibroblasts by defined factors [J]. Cell, 2007, 131:861 -872.
  • 5Lin T, Ambasudhan R, Yuan X, et al. A chemical plat- form for improved induction of human iPSCs [ J ]. Nat Methods, 2009, 6: 805- 808.
  • 6Shi Y, Do JT, Desponts C, et al. A combined chemical and genetic approach for the generation of induced pluripo- tent stem cells [ J ]. Cell Stern Cell, 2008,2:525 - 528.
  • 7Zhu SY, Li WL, Zhou HY, et al. Reprogramming of hu- man primary somatic cells by OCT4 and chemical com- pounds [J]. Cell Stem Cell, 2010, 7:651 -655.
  • 8Ieda M, Fu JD, Delgado-Olguin P, et al. Direct repro- gramming of fibroblasts into functional cardiomyocytes by defined factors [J]. Cell, 2010, 142:375-386.
  • 9Vierbuchen T, Ostermeier A, Pang ZP, et al. Direct con- version of fibroblasts to functional neurons by defined fac- tors [J]. Nature, 2010, 463:1035 - 1041.
  • 10姜开军,王菊,周宗瑶.胚胎干细胞增殖分化相关基因[J].基础医学与临床,2008,28(3):294-296. 被引量：2

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基础医学与临床
2010年 第2期

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